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Accomplishments

Accomplishments

Preclinical Contract Research Organization Accomplishments

Preclinical Translational Services is a full-service preclinical contract research organization (CRO) that combines the power of a traditional CRO with the unique ability to draw on scientific faculty to solve the most complex problems. In particular, we have been able to develop expertise in recent years in preclinical surgical services. We also have experience in comparative medicine, focusing on nonhuman primate models for more than 60 years.

With the expertise of our faculty, we are equipped to solve complex problems and get solutions to patients quickly and in a cost-effective way for business.

Range of Services: Proof-of-principle study design, method development, model creation, and device, therapeutic, and vaccine testing.

Latest Techniques: Bench analysis, ex-vivo modeling, dynamic imaging, extensive surgical models, wide range of innovative animal models.

Great Business Partner: Cost effective studies, fast delivery times, complete confidentiality, rapid response on quotes and contracts.

History and Preclinical Experience

Preclinical Translational Services has long employed an experienced core research team trained in good laboratory practices and using our state-of-the-art facilities.

  • Not only are we the only university-based nonhuman primate center in the mid-Atlantic, but in 1959 our School of Medicine became the first to ever offer training in laboratory animal medicine in the country. That has translated into more than 60 years of experience in developing models for the study of disease, with a focus on chronic and degenerative diseases.
  • In medical devices, we are committed to providing superior study design and surgery, leading to reliable results in the safety and efficacy evaluation of new medical devices.
  • Our biomolecular imaging capabilities have likewise developed over decades. Currently, several large bench laboratories and multiple small bench laboratories are spread across three separate facilities. They are used for the production of radionuclides and radiopharmaceuticals, the manufacture of MRI coils and hardware; an image analysis lab and a cyclotron are included. These laboratories are equipped with the latest technologies.

Surgical Services Accomplishments

  • Cardiovascular and thoracic technologies and techniques; specializing in protocols that are scientifically complex
  • Preclinical investigations and clinical studies management, with study design capability for in vivo and ex vivo testing and evaluation
  • Expert training in non-clinical surgical research

Comparative Medicine Accomplishments

  • First to establish that coronary artery remodeling occurs in both human and nonhuman primates; finding has a major role in determining whether progressing atherosclerosis will lead to coronary heart disease and death.
  • Our team provided the first data that suggested psychosocial stress exacerbates the development of coronary artery atherosclerosis in males and does so via arousal of the sympathetic nervous system.
  • Our team developed the nonhuman primate as a model for vulnerability to breast cancer and produced the first evidence that estrogen plus a particular type of progestin therapy (medroxyprogesterone acetate – MPA) – induces abnormal breast proliferation. This observation preceded by several years the same outcome in the Women’s Health Initiative.
  • Our team discovered that prior use of oral contraceptives (OC) produces long-term effects on estrogen metabolism in monkeys that persist three years after cessation of OC use. This novel finding may shed light on why OC use protects against certain cancers (endometrium and ovary).