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Cardiovascular Preclinical Models

Cardiovascular Preclinical Models

Cardiovascular disease—including coronary heart disease, stroke, and heart failure—remains the leading cause of death in most of the world. Our team has pioneered the development and application of numerous preclinical models, especially nonhuman primates and transgenic mice, to the investigation of cardiovascular disease and the underlying atherosclerosis. Our experience includes:

  • Formulation of specialized diets
  • Highly refined approaches to behavioral assessment
  • Use of advanced imaging modalities and surgical techniques
  • Extensive validation of cardiovascular biomarkers

We are capable of evaluating the effect of a wide range of therapeutic interventions on vascular structure and function in studies of any scale and using models ranging from rodents to nonhuman primates. These studies are supported by state-of-the-art animal housing and surgical facilities, an internationally recognized group of veterinary pathobiologists and proven analytical methods. Our experienced clinical and experimental specialists will collaborate with you to design a study matched to your specific needs that will produce fast and accurate results.

Preclinical Models for Atherosclerosis

  • Model platforms include transgenic mice, pigs and various species of monkeys
  • Effects of diet and dietary components
  • Effect of therapeutic agents including hormones, small molecules and antibodies
  • Effects of psychosocial stress, including depression and individual differences in temperament

Preclinical Surgical Models

  • Models of acute myocardial infarction (with or without reperfusion)
  • Heart valve studies
  • Peripheral arterial disease
  • Thrombosis models
  • Venous/arterial grafts
  • Coronary artery bypass
  • Cardiopulmonary bypass
  • Cardiac assist devices
  • Microvascular surgery
Ready to take the next step? Schedule a meeting with Wake Forest Innovations or contact us at or call +1.336.713.1111.