Type 2 diabetes (known as T2D or so-called adult onset diabetes) accounts for up to 95 percent of all diagnosed cases of diabetes in the U.S., affecting almost 10 percent of our population. Environmental factors such as the typical American diet and lack of physical activity are believed to account for the alarming rise in the incidence of T2D and the obesity that often precedes it. The Preclinical Translational Services team has had more than two decades of experience in the development and application of preclinical models of T2D and in the evaluation of therapeutic interventions, including those involving diet and exercise.
Our work in this area has focused primarily on cynomolgus macaques (Macaca fascicularis) and Caribbean-origin, African green monkeys (Chlorocebus aethiops). Importantly, we are able to provide T2D-susceptible monkeys of both species as model platforms. We also have experience with streptozotocin-induced insulin insufficiency.
The Preclinical Translational Services team will work with you to choose the species and diet best suited to your needs. Cynomolgus monkeys are susceptible to diet induction of atherosclerosis and therefore are particularly useful for studying the effect of therapeutic interventions on the interaction between diabetes and atherosclerosis. Although African green and cynomolgus monkeys are equally susceptible to T2D, African green monkeys are also highly vulnerable to hypertension. Furthermore, we can make available for study African green monkeys that are genetically defined (i.e., drawn from a pedigreed population in which all animals have been subjected to whole genome sequencing and SNP generation).