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Cancer Research

Cancer Research

Our Preclinical Cancer Research Expertise

  • Multiple nonhuman primate and rodent models of cancer
  • Genetic/familial models of cancer
  • Chemical- and radiation-induced cancers
  • Customized cohort development
  • Xenotransplantation models
  • Platforms for testing novel chemotherapeutic agents
  • Platforms for studying the radiation response of tumors
  • Immunological services for the study of cancer vaccines and antibodies
  • State-of-the-art imaging modalities, including MRI, CT, DXA and PET
  • Cutting-edge laboratory facilities and capabilities

Multiple nonhuman primate models for cancer are available at Wake Forest Baptist

Wake Forest Baptist Medical Center is one of the nation’s leaders in the fight against cancer. Ranked first in North Carolina for its cancer program, and twentieth nationwide, Wake Forest Baptist has pioneered numerous scientific breakthroughs in the understanding and treatment of cancer.

With over 120 dedicated clinicians and scientific experts, we offer the most advanced cancer research and drug development services available to industry partners. Our scientists, veterinarians and surgeons who collaborate as part of our multidisciplinary Comprehensive Cancer Center use the state-of-the-art facilities and capabilities of Wake Forest Baptist to manage top-tier preclinical studies for industry sponsors, including our 200-acre nonhuman primate center and access to multiple nonhuman primate models of cancer, a full-service pathology laboratory that can provide histological analysis of tumors, state-of-the-art imaging modalities and cutting-edge laboratory tools for genetic analysis.

Cancer Research Faculty Experts

Tumor Progression and Recurrence

Martha Alexander-Miller, PhD, an expert in immunity, is developing an influenza vaccine designed for infants younger than six months. For this research, her team established a preclinical neonatal nursery, possibly the only one in the world dedicated to translational sciences. Alexander-Miller seeks industry partners for both her discoveries and for research utilizing the capabilities of the preclinical neonatal nursery.

Mark Cline, DVM, PhD: Professor of Pathology – Comparative Medicine with expertise and interest in diabetes; therapeutic agents and pharmaceuticals; and infectious diseases

Waldemar Debinski, MD, PhD, director of the Brain Tumor Center of Excellence and professor of neurosurgery at Wake Forest School of Medicine, pioneers the use of targets in malignant brain tumor cells that are not present in normal brain to destroy them effectively and safely.

Purnima Dubey, PhD, Associate Professor of Pathology with research interests in cancer; immunology; vaccines; and infectious disease

Patricia Gallagher, PhD, and Ann Tallant, PhD, Professors of Hypertension with expertise and interest in cancer research; cardiac function; cell growth; vascular diseases; women’s health issues; and specific expertise in Angiotensin(1-7)

Karen Haas, PhD,  Assistant Professor of Microbiology & Immunology with research interests in vaccines; immunology; hormones, cytokines and signaling; and atherosclerosis

Greg Hawkins, PhD, Associate Professor with the Center for Genomics and Personalized Medicine Research with expertise and interest in genetics and the genome; and hormones, cytokines and signaling

Linda Methany-Barlow, PhD, Associate Professor of Radiation Oncology with research interest in cancer; cognition and learning; molecular biology; and women’s health issues

David Ornelles, PhD, Associate Professor of Microbiology & Immunology with research interests in cancer; cell growth; infectious disease; vaccines; molecular biology; and growth and development

John Parks, PhD, Professor of Molecular Medicine with research interests in atherosclerosis; diabetes; therapeutic agents; hormones, cytokines and signaling; immunology; metabolism; nutrition; obesity; transgenics; and vascular diseases

Cancer Biology and Biochemistry

Samuel Deadwyler, PhD, and Robert Hampson, PhD, study the neurophysiological basis of memory, behavior and cognition by developing animal models and neural prosthetics. They record neuron patterns in the hippocampus and prefrontal cortex and design devices to help restore the cognitive function lost due to brain disease, damage and disorders. They also research drugs of abuse, cognitive-enhancing drugs, sleep deprivation and whole-brain irradiation.

Steven Kridel, PhD, Associate Professor of Cancer Biology with research interests in cancer; metabolism; and molecular biology and molecular medicine

Gregory Kucera, PhD, Professor of Hematology & Oncology with research interests in alternative medicine; cancer; nutrition; and women’s health issues

Nicole Levi, PhD, Assistant Professor of Plastic & Reconstructive Surgery with research interests in biotechnology; cancer; therapeutic agents; and medical technologies and devices

Akiva Mintz, MD, PhD, Associate Professor of Radiology with research interests in molecular imaging; noninvasive imaging; nuclear medicine; oncologic imaging; and PET/CT

David Soto Pantoja, PhD, Assistant Professor of Hypertension with research interests in cancer; cell growth; differentiation; and metabolism

Explore Industry Research Collaboration at Wake Forest

  • We offer customized research teams of renowned scientists, veterinarians and oncologists, experienced technicians and an industry-supportive alliance management team.
  • Our Preclinical Translational Services surgical group provides high-caliber investigative surgical services, with specialized experience in large animal models such as pigs, sheep and nonhuman primates.
  • We house multiple animal models, including nonhuman primates for cancer research, at our Clarkson Campus.
  • We have the institutional expertise and resources to design and manage custom cohorts of animal models for our preclinical research studies.
  • Industry-sponsored and contract preclinical research studies conducted here utilize the latest in basic and imaging technologies available at Wake Forest Baptist’s core labs and imaging facilities.