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Our Preclinical Orthopaedic Models and Procedures

We offer the following models and procedures for industry partners developing new drugs and procedures for all areas of orthopaedic intervention:

Joint Models

  • Osteoarthritis
  • Arthroplasty (hip, knee) and other types of articular cartilage repair
  • Anterior cruciate ligament (ACL) repair/meniscectomy
  • Artificial meniscus
  • Reconstruction/fixation of other ligaments and tendons
  • Artificial ligaments and tendons

Bone Defect Models

  • Osteotomy of femur, tibia and radius
  • Critical size defect models in the calvarium, tibia, fibula, femur, radius and ulna

Spinal Fusion Models

  • Posterior lumbar interbody fusion

Preclinical orthopaedic research services at Wake Forest Baptist

Wake Forest Baptist Medical Center researchers and clinicians provide high-caliber expertise in the assessment of orthopaedic medical devices and surgical procedures. We develop customized research teams of scientists, veterinarians and preclinical and clinical surgeons to better understand the value of industry’s medical products.

We have distinct expertise in medical device assessment and arthritis research in rodents, sheep and nonhuman primates. Our clinical faculty offer industry the value of a clinical perspective on their medical products. Our studies utilize world-class imaging technologies available at Wake Forest Baptist (e.g., PET, custom radiolabeling, cyclotron, CT and MRI at dedicated imaging facilities). Our state-of-the-art pathology laboratory provides histological and histomorphometric analyses, and our biomechanics laboratory provides torsional testing of bone and joint interventions.

Preclinical Orthopaedic Faculty Experts

Thomas Smith, PhD: Professor of Orthopaedics with research interests in critical and intensive care, research outcomes and surgical procedures

Jeffrey Willey, PhD: Assistant Professor of Radiation Oncology with research interests in arthritis, cancer, therapeutic agents and osteoporosis

Kerry Ann Danelson, PhD: Assistant Professor of Orthopaedics with research interests in bioengineering and research outcomes

Explore Industry Research Collaboration at Wake Forest

We offer customized research teams of renowned scientists, veterinarians and clinicians, experienced technicians and an industry-supportive alliance management team.

Our Preclinical Translational Services surgical group provides high-caliber investigative surgical services, with specialized experience in large animal models such as pigs, sheep or nonhuman primates.

We house multiple large animal models and can facilitate GLP-compliant large animal studies at our Clarkson Campus.

We have the institutional expertise and resources to design and manage custom cohorts of animal models for our preclinical research studies.

Industry-sponsored and contract preclinical research studies conducted here utilize the latest in basic science and imaging technologies available at Wake Forest Baptist’s core labs and preclinical imaging facilities.