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Preclinical Imaging

Preclinical Imaging

Get access to the full range of state-of-the-art preclinical imaging technologies and expertise available at Wake Forest Baptist Medical Center through its Translational Imaging Program.

Access state-of-the-art preclinical imaging technologies at Wake Forest Baptist

The faculty and technicians at Wake Forest Baptist have broad experience with all imaging modalities commonly used in rodent, nonhuman primate and other animal models (e.g. PET, CT and MRI). We also have optimized additional modalities (such as MEG and IVUS) for cardiovascular endpoints, especially in nonhuman primates.

Selected preclinical imaging technologies include:

Magnetic Resonance Imaging (MRI)

A Siemens MAGNETOM Skyra 3T MRI Scanner with TIM Technology operated by dedicated magnetic resonance-registered technologists with experience in all aspects of magnetic resonance imaging research and preclinical imaging techniques

A Bruker Biospin micro-MRI scanner that provides preclinical imaging for a variety of platforms with sub-0.1mm resolution and is staffed by experts in a number of cutting-edge imaging techniques, including magnetically-labeled cell tracking, cardiac and atherosclerosis imaging, proton spectroscopy and Diffusion Tensor Imaging (DTI).

Computed Tomography (CT) and Positron Emission Tomography (PET)

A 32-slice Toshiba Aquilion CT Scanner dedicated to preclinical imaging, offering 32 slices per rotation at 0.5mm using high resolution scanning mode, a gantry speed of 0.5 seconds and equipped with cardiac gating

A GE 16-slice PET/CT Discovery ST Scanner operated by a Nuclear Medicine-registered technologist with 24 detector rings that provide 47 contiguous image planes over a maximum 70 cm transaxial field of view with CT attenuation correction

A GE PETtrace 10 Cyclotron that allows fast, easy, efficient in-house production of radioisotopes for all of our clients’ needs

Two organic chemistry laboratories and a radiochemistry laboratory that provide support for the conception and design of novel radiopharmaceuticals for use in PET imaging, as well as a laboratory containing a Varian Analytical HPLC (attached with UV and radioisotope detectors) and a Packard Cobra II auto-gamma counter for metabolite analysis

Magnetoencephalography (MEG)

A CTF MEG 2005 model instrument equipped with 275 first-order axial-gradiometers and the capability of simultaneous acquisition of 64-channel EEG, along with all necessary infrastructure for conducting preclinical studies, including anesthesia equipment and supplies

Vevo LAZR Photoacoustic Imaging

Photoacoustic imaging integrates the sensitivity of light-based imaging with the resolution of high-frequency sound waves to provide never-before-seen insights into cellular environment and flow of blood. This kind of imaging produces the non-invasive functional, anatomic and visual information needed to assess potential treatments for the major diseases that affect people around the world.

Imaging Bioinformatics

The Imaging Bioinformatics section at the Center for Biomolecular Imaging provides all the tools you need to view your images and quantify your data for accurate analysis. Technology includes three TeraRecon AquariusNET servers, which provide distributed 2D/3D/4D real-time rendering and visualization on any Windows PC via a local network and can concurrently 3D render approximately 27,600 images in real time. These servers can also render images from any modality in 3D from a stack of 2D DICOM images and provide image fusion and JPEG and AVI outputs. Other image analysis software includes OsiriX 3.7.1, Mimics 13, Amira 3.1, ImageJ 1.4.3, LCModel 6.1, MIPAV 4.0.2 and Autodesk Maya 9.